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con-PDmode: Control-oriented PD state modelling and estimation for precision medicine
Parkinson's disease (PD) is a progressive neurodegenerative disorder and constitutes a serious public health concern. Although there are various methods on the market for evaluating disease symptoms using wearable sensors, these technologies are difficult to use, expensive and often require specific hardware. The EU-funded con-PDmode project aims to address these limitations by developing software capable of accounting for inaccuracies and uncertainty in the data collected from low-cost wearable sensors. Using advanced techniques, scientists will generate a modelling approach for evaluating PD symptoms and disease state, information on which will be communicated back to the patient. Optimisation of the algorithms and user interface as well as rigorous testing will ensure the development of an accurate PD assessment tool.
Motivation
Despite the fact that there has been some progress in developing methods for estimating Parkinson’s disease (PD) symptoms using wearable sensors, these technologies have not sufficiently penetrated the market due to the usability of the system and its cost; existing technologies are constrained by specific hardware requirements or user activities, therefore aversively affecting the cost and usability of the technologies, respectively. Thus, Con-PDmode delivers a software prototype for control-oriented modelling and estimation of PD symptoms that are transparent and platform agnostic. The excellence in innovation potential for successfully bringing the PD assessment tool to the market is the capability to account for inaccuracies and uncertainty in the data collected from low-cost wearable sensors. To this purpose, we will adapt and implement advanced stochastic techniques for improved robustness in state estimation, the confidence level of the model estimation will be transparently communicated to its users. We will perform iterative tests in various environmental and sensor configurations to refine our algorithms as well as the user interface.
Team members
- Sandra Hirche (principal investigator)
- Satoshi Endo
- Neha Das
- Armin Lederer
Alumni
- Miruna Werkmeister
Student members
Past Student assistant
- B.Sc. Varsha Raveendran (2021)
- B.Sc, Arnabesh Das (Oct 2022 - Feb 2023)
Currently available student thesis / research internship
No thesis topic is currently available...
Selected publications
This research is supported by the European Union’s ERC Proof of Concept Grant under grant agreement no 899260.
For further information, see https://cordis.europa.eu/project/id/899260